The Microphthalmia-associated Transcription Factor (mitf) Requires Swi/snf Enzymes to Activate Melanocyte Specific Genes
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The microphthalmia-associated transcription factor requires SWI/SNF enzymes to activate melanocyte-specific genes.
The microphthalmia transcription factor (Mitf) activates melanocyte-specific gene expression, is critical for survival and proliferation of melanocytes during development, and has been described as an oncogene in malignant melanoma. SWI/SNF complexes are ATP-dependent chromatin-remodeling enzymes that play a role in many developmental processes. To determine the requirement for SWI/SNF enzymes ...
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تاریخ انتشار 2006